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Novel association between blastocystosis and some hemogram parameters in Iraqi people with and without irritable

Masar Hadi Ismail1, Shatha Khudaier Abbas1, Abdul-Lateef Molan2

  • 1Department of Biology, College of Sciences, Mustansiriyah University, Baghdad, Iraq.

Annals of Parasitology
|December 30, 2022
PubMed

Insights

Blastocystis parasites significantly alter key blood cell counts, including lymphocytes, platelets, monocytes, and neutrophils. These changes, along with elevated ratios like neutrophil-to-lymphocyte ratio (NLR), may serve as novel markers for blastocystosis.

Area of Science:

  • Medical Parasitology
  • Hematology
  • Gastroenterology

Background:

  • Blastocystis parasites are implicated as pathogenic protozoa, with potential links to anemia.
  • Irritable Bowel Syndrome (IBS) is a common gastrointestinal disorder.
  • Hematological indices may be affected by parasitic infections.

Purpose of the Study:

  • To compare hematological indices in healthy individuals, Blastocystis-positive subjects, Blastocystis-negative IBS patients, and Blastocystis-positive IBS patients.
  • To evaluate the correlation between blastocystosis and specific hemogram parameters.
  • To identify potential novel markers for Blastocystis infection.

Main Methods:

  • Blood samples were collected from four groups: healthy controls, Blastocystis-positive subjects, Blastocystis-negative IBS patients, and Blastocystis-positive IBS patients.
  • Complete blood count (CBC) was measured for all participants.
  • Six hemogram parameters were analyzed: monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), red cell distribution width (RDW), platelet distribution width (PDW), and mean platelet volume (MPV).

Main Results:

  • Blastocystis infection led to significant decreases in lymphocytes and platelets, and significant increases in monocytes and neutrophils compared to healthy controls.
  • NLR, MLR, PLR, RDW, PDW, and MPV were significantly higher in Blastocystis-infected individuals (both IBS and non-IBS) compared to their Blastocystis-negative counterparts.
  • These findings were observed for the first time.

Conclusions:

  • Elevated levels of NLR, MLR, PLR, RDW, PDW, and MPV can potentially serve as novel diagnostic markers for blastocystosis.
  • Blastocystis parasite infection significantly impacts hematological indices in both IBS patients and non-IBS individuals.

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