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Association of Matrix Metalloproteinase-2 Genotypes With Prostate Cancer Risk
Po-Han Li1,2, Cheng-Hsi Liao1,3,4, Wen-Chin Huang1,5
1Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Anticancer Research
|December 30, 2022
Summary
This study found no significant association between specific matrix metalloproteinase-2 (MMP-2) gene variants and prostate cancer (PCa) risk in a Taiwanese population. MMP-2 genotypes did not influence individual PCa susceptibility.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- Prostate cancer (PCa) is a prevalent malignancy in males.
- Matrix metalloproteinase-2 (MMP-2) is implicated in cancer metastasis.
- Genetic variations in MMP-2 have not been extensively studied in relation to PCa risk.
Purpose of the Study:
- To investigate the association between MMP-2 promoter genotypes (rs243865 and rs2285053) and prostate cancer risk.
- To analyze genotype and allele frequencies in a Taiwanese cohort.
- To determine if MMP-2 genotypes correlate with PCa risk, age, or smoking status.
Main Methods:
- Case-control study design.
- Genotyping of MMP-2 rs243865 and rs2285053 using polymerase chain reaction-restriction fragment length polymorphism.
- Analysis of 218 PCa patients and 436 healthy controls.
Main Results:
- No significant association was found between MMP-2 rs243865 genotypes (CC, CT, TT) and PCa risk (p=0.5544).
- The variant T allele of MMP-2 rs243865 was not linked to PCa risk (p=0.3250).
- MMP-2 rs2285053 genotypes also showed no significant association with PCa risk. No correlation with age or smoking status was observed.
Conclusions:
- The studied MMP-2 promoter polymorphisms (rs243865 and rs2285053) appear to play a minor role in determining prostate cancer risk in the Taiwanese population.
- Further research may be needed to explore other genetic factors influencing PCa susceptibility.
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