Related Experiment Video
Updated: Aug 15, 2025
CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
Published on: April 25, 2022
Association of Matrix Metalloproteinase-7 Genotypes With Prostate Cancer Risk
Cheng-Hsi Liao1,2,3, Wen-Shin Chang4, Wei-Lin Hsu5
1Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Background/Aim:
Prostate cancer is one of the most commonly diagnosed malignancies among males worldwide. It has been shown that MMP-7 gene is closely correlated with prostate carcinogenesis. However, the role of the MMP-7 genotypes has been seldom examined among prostate cancer patients. Therefore, the purpose of the study was to evaluate the contribution of MMP-7 promoter genotypes A-181G (rs11568818) and C-153T (rs11568819) to prostate cancer risk in Taiwan.
Materials And Methods:
Two hundred and eighteen prostate cancer patients and 436 sex- and age-matched healthy controls were genotyped for MMP-7 rs11568818 and rs11568819 by polymerase chain reaction-restriction fragment length polymorphism and direct sequencing methodologies.
Results:
The percentages of wild-type AA, and variant AG and GG genotypes on MMP-7 rs11568818 were 85.3, 13.5, and 1.2% among the prostate cancer cases and 87.6, 10.1, and 2.3% among the healthy controls, respectively (p for trend=0.2557). Interestingly, no MMP-7 rs11568819 genotypes were identified among Taiwanese. The allelic frequency distribution also showed that the variant G allele of MMP-7 rs11568818 seemed not to be a determinant of prostate cancer risk (p=0.7977). There was no joint effect between the genotypes of MMP-7 rs11568818 and age and smoking status on prostate cancer risk.
Conclusion:
rs11568818 and rs11568819 at MMP-7 promoter region, played no role in determining personal susceptibility to prostate cancer in Taiwan.
Insights
This study investigated matrix metalloproteinase-7 (MMP-7) gene variants and prostate cancer risk in Taiwan. The MMP-7 promoter genotypes A-181G and C-153T did not influence prostate cancer susceptibility in the Taiwanese population.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- Prostate cancer is a prevalent malignancy globally.
- The matrix metalloproteinase-7 (MMP-7) gene is implicated in prostate carcinogenesis.
- Limited research exists on the impact of MMP-7 genotypes on prostate cancer risk.
Purpose of the Study:
- To investigate the association between MMP-7 promoter genotypes A-181G (rs11568818) and C-153T (rs11568819) and prostate cancer risk.
- To evaluate the role of these MMP-7 genotypes in the Taiwanese population.
Main Methods:
- Genotyping of 218 prostate cancer patients and 436 healthy controls for MMP-7 rs11568818 and rs11568819.
- Utilized polymerase chain reaction-restriction fragment length polymorphism and direct sequencing.
- Analyzed allelic frequencies and genotype distributions.
Main Results:
- No MMP-7 rs11568819 genotypes were detected in the Taiwanese subjects.
- The variant G allele of MMP-7 rs11568818 was not a significant determinant of prostate cancer risk (p=0.7977).
- No interaction was found between MMP-7 rs11568818 genotypes, age, and smoking status regarding prostate cancer risk.
Conclusions:
- The studied MMP-7 promoter genotypes (rs11568818 and rs11568819) do not play a role in determining individual susceptibility to prostate cancer in Taiwan.
- These specific MMP-7 genetic variations are unlikely to be predictive biomarkers for prostate cancer risk in this population.
