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Updated: Aug 15, 2025
Long-term Intravital Immunofluorescence Imaging of Tissue Matrix Components with Epifluorescence and Two-photon Microscopy
Published on: April 22, 2014
Multiscale Label-Free Imaging of Fibrillar Collagen in the Tumor Microenvironment
Michael S Nelson1,2, Yuming Liu1, Helen M Wilson1,2
1Center for Quantitative Cell Imaging, University of Wisconsin-Madison, Madison, WI, USA.
Advanced imaging techniques are crucial for understanding cancer progression by analyzing collagen structure. Label-free methods offer clinically relevant insights into collagen
Area of Science:
- Biomedical Engineering
- Cancer Biology
- Medical Imaging
Background:
- Collagen, a key component of the tumor microenvironment, has complex roles in cancer progression, influencing invasion and metastasis.
- Tumor-associated collagen deposition and fiber organization impact cancer onset, progression, and therapeutic response.
- Accurate characterization of collagen structure is vital for developing effective cancer therapeutics.
Conclusions:
- Imaging collagen structure at both bulk and microscale levels is essential for understanding cancer.
- Clinically amenable, label-free imaging techniques are critical for advancing cancer diagnostics and therapeutics.
- Further integration of microscale collagen imaging into clinical practice holds significant potential for improved cancer care.
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