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A review on taste masked multiparticulate dosage forms for paediatric
Khater Al-Japairai1, Samah Hamed Almurisi2, Abd Almonem Doolaanea3
1Department of Pharmaceutical Engineering, Faculty of Chemical and Process Engineering Technology, Universiti Malaysia Pahang, Gambang 26300, Malaysia.
International Journal of Pharmaceutics
|January 1, 2023
Summary
Pediatric patients often refuse medication due to unpleasant tastes. Taste-masked multiparticulate dosage forms offer a solution by improving palatability and ease of administration for children.
Area of Science:
- Pharmaceutical Sciences
- Pediatric Drug Delivery
- Formulation Development
Background:
- Unpleasant drug taste is a significant barrier to medication adherence in pediatric populations.
- Pharmaceutical product acceptability depends on factors like taste, texture, swallowability, and appearance.
- Multiparticulate dosage forms are a versatile platform for addressing pediatric administration challenges.
Purpose of the Study:
- To review the key considerations for developing taste-masked multiparticulate dosage forms specifically for pediatric use.
- To highlight the advantages of multiparticulate systems in improving pediatric medication acceptance.
- To discuss strategies for overcoming taste-masking challenges in pediatric formulations.
Main Methods:
- Literature review of scientific publications on taste masking and multiparticulate drug delivery systems.
- Analysis of formulation strategies for enhancing palatability in pediatric medications.
- Discussion of manufacturing considerations for taste-masked multiparticulate dosage forms.
Main Results:
- Multiparticulate systems effectively mask unpleasant tastes and improve swallowability in pediatric patients.
- Various taste-masking techniques can be applied to multiparticulate formulations.
- Successful development requires careful consideration of excipients, manufacturing processes, and patient-specific factors.
Conclusions:
- Taste-masked multiparticulate dosage forms represent a promising approach to improve pediatric medication adherence.
- Optimizing formulation and manufacturing is crucial for successful pediatric taste-masked drug delivery.
- Further research into novel taste-masking technologies for multiparticulate systems is warranted.
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