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Prevalence and clinical features of hemicrania continua in clinic-based studies: A systematic review and

Haidar Muhsen Al-Khazali1, Sarra Al-Khazali1, Afrim Iljazi1

  • 1Danish Headache Center, Department of Neurology, Rigshospitalet - Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Cephalalgia : an International Journal of Headache
|January 2, 2023
PubMed

Insights

Hemicrania continua is identified in 1.8% of adult headache patients in clinic settings. Common symptoms include lacrimation, conjunctival injection, and agitation, but more data is needed.

Area of Science:

  • Neurology
  • Epidemiology
  • Headache Medicine

Background:

  • Hemicrania continua is a rare, continuous headache disorder.
  • Accurate prevalence data is lacking, hindering clinical recognition and management.
  • Understanding its frequency and features in clinical settings is crucial.

Approach:

  • A systematic review and random-effects meta-analysis was performed.
  • Searched PubMed and Embase for clinic-based studies from 2004-2022.
  • Included 11 studies with 9854 adult headache patients.

Key Points:

  • The pooled relative frequency of hemicrania continua was 1.8% (95% CI; 1.0-3.3).
  • Significant heterogeneity was observed across studies (I² = 89.8%).
  • Most common clinical features were lacrimation (72.3%), conjunctival injection (69.8%), and restlessness/agitation (60.2%).

Conclusions:

  • Limited epidemiologic data exists for hemicrania continua.
  • Standardized data collection is essential for accurate prevalence estimation.
  • Increased awareness is needed to improve clinical practice and patient outcomes.
Abstract

Keywords:
International Classification of Headache DisordersTrigeminal autonomic cephalalgiaepidemiologyheadacheprimary headache disorders

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