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In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
Iridociliary measurements using the Anterion swept-source optical coherence tomography
Sagarika Patyal1, Arun Kumar Yadav2, Hansel Anthony3
1Centre for Sight, New Delhi, India.
This pilot study demonstrates the feasibility of the Anterion swept-source OCT device for accurately measuring anterior segment structures like the ciliary body and iris. These measurements are valuable for ophthalmologists in diagnosing and treating eye conditions.
Area of Science:
- Ophthalmology
- Medical Imaging
- Biomedical Engineering
Background:
- Anterior segment optical coherence tomography (AS-OCT) using swept-source technology offers advanced visualization capabilities.
- Accurate measurement of ocular structures is crucial for diagnosing and managing various eye diseases.
Purpose of the Study:
- To evaluate the feasibility of a new swept-source OCT device (Anterion) for measuring key anterior segment parameters.
- Specifically assess the device's ability to measure iris ciliary sulcus, ciliary body thickness, and iris thickness.
Main Methods:
- A pilot study involving 30 healthy young participants and hospital employees was conducted.
- Measurements of iris thickness (at two locations), ciliary body thickness, and iridociliary sulcus were performed using the Anterion device.
- Data quality was assessed, with 28 participants providing good-quality results for analysis.
Main Results:
- The Anterion device provided reliable measurements for iris thickness, ciliary body thickness, and iridociliary sulcus.
- Specific measurements included iris thickness (e.g., 0.70 ± 0.10 mm at 2.5 mm from the pupillary margin) and ciliary body thickness (0.59 ± 0.14 mm).
- Iridociliary sulcus angles were recorded as approximately 82.65 ± 26.6° (right eye) and 83.66 ± 30.1° (left eye).
Conclusions:
- The Anterion swept-source OCT device is feasible for anterior segment measurements in a clinical setting.
- The device provides valuable data that can aid ophthalmologists in patient diagnosis and treatment planning.
- This technology holds promise for enhancing the management of ocular conditions.
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