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Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications

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Electrospun Polylactic Acid-Based Fibers Loaded with Multifunctional Antibacterial Biobased Polymers.

A Chiloeches^1,2, R Cuervo-Rodríguez³, Y Gil-Romero⁴

¹Instituto de Ciencia y Tecnología de Polímeros (ICTP-CSIC), C/Juan de la Cierva 3, 28006 Madrid, Spain.

ACS Applied Polymer Materials

|January 2, 2023

Summary

This summary is machine-generated.

Researchers developed antibacterial and compostable polylactic acid (PLA) fibers using a novel biobased polymer. These functionalized fibers show broad-spectrum antibacterial activity and maintain biodegradability, offering potential for medical applications.

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Area of Science:

Materials Science
Polymer Chemistry
Biotechnology

Background:

Developing effective antibacterial materials is crucial for medical applications.
Biodegradable polymers like polylactic acid (PLA) are desirable for sustainable materials.
Incorporating antimicrobial properties into biodegradable polymers without compromising compostability is a challenge.

Purpose of the Study:

To create antibacterial and compostable electrospun polylactic acid (PLA) fibers.
To synthesize a multifunctional biobased polymer for antibacterial applications.
To evaluate the antibacterial efficacy and compostability of the developed PLA fibers.

Main Methods:

Synthesis of a multifunctional biobased polymer from itaconic acid via radical polymerization and click chemistry.
Incorporation of the polymer into PLA solutions for electrospinning fiber mats.
Surface modification of fibers to introduce cationic triazolium and N-halamine groups for antibacterial activity.
Testing antibacterial activity against Gram-positive and Gram-negative bacteria.
Assessing fiber compostability under industrial composting conditions.

Main Results:

Successful preparation of electrospun PLA fiber mats containing the biobased polymer.
Fibers exhibited potent antibacterial activity against both Gram-positive and Gram-negative bacteria after surface modification.
Cationic groups were effective against Gram-positive bacteria, while N-halamine groups significantly enhanced activity against Gram-negative bacteria.
The incorporation of the antibacterial polymer did not hinder the compostability of the PLA fibers.

Conclusions:

A novel biobased polymer can impart significant antibacterial properties to PLA fibers.
The developed PLA fibers are both antibacterial and compostable, suitable for medical applications.
This approach offers a sustainable solution for creating functional biodegradable materials.