THE METHOD OF ATOMIC FORCE MICROSCOPY AS A POSSIBLE TOOL FOR TESTING THE BIOCOMPATIBILITY OF IMPLANTS IN TRAUMATOLOGY...

Area of Science:

• Biomaterials Science
• Medical Diagnostics
• Nanotechnology

Background:

• Orthopedic implant success depends on biocompatibility.
• Predicting patient-implant interaction is crucial for clinical outcomes.
• Current biocompatibility testing can be time-consuming.

Purpose of the Study:

• To evaluate the potential of Atomic Force Microscopy (AFM) in predicting the host's response to orthopedic implants.
• To establish AFM as a tool for assessing implant biocompatibility.
• To investigate the correlation between AFM findings and inflammatory markers.

Main Methods:

• Atomic Force Microscopy (AFM) was employed for pre- and post-operative testing.
• Biocompatibility of orthopedic implant materials was assessed in 32 patients (22 men, 10 women; average age 55±6 years).
• Analysis focused on detecting changes in pro-inflammatory factors.

Main Results:

• An increase in pro-inflammatory factors was observed, suggesting a persistent inflammatory response.
• This inflammatory response is likely associated with the presence of the orthopedic implant.
• AFM detected changes indicative of the body's reaction to the implant material.

Conclusions:

• Atomic force spectroscopy provides an rapid method for testing biomaterial compatibility for individual patients.
• This technique allows for the study of recipient tissue reactions on implant surfaces.
• The findings support the use of AFM in planning future clinical trials for implant development.