Higher Prevalence of Generalized Pustular Psoriasis in Asia? A Population-Based Study Using Claim Data in China and a...

Area of Science:

• Dermatology
• Epidemiology
• Public Health

Background:

• Generalized pustular psoriasis (GPP) is a severe, life-threatening skin condition with limited data on its national burden.
• Understanding GPP's epidemiology is crucial for effective public health strategies.

Approach:

• A population-based study analyzed Urban Basic Medical Insurance data in China (2012-2016) to determine GPP prevalence and incidence.
• International Classification of Diseases codes (ICD-10: L40.1, ICD-9: 694.3) were used for GPP case identification.
• A systematic review of published literature up to January 2022 was conducted to compare GPP burden globally.

Key Points:

• In 2016, GPP crude prevalence was 1.403 and incidence was 0.629 per 100,000 person-years in China.
• Prevalence and incidence were higher in males and showed a bimodal age distribution, peaking in 0-3 and 30-39 year-olds.
• The annual per capita cost for GPP patients was approximately $609.26 USD. GPP prevalence appears higher in Asian countries compared to others.

Conclusions:

• This study represents the largest investigation into the disease burden of GPP.
• While the direct economic burden was moderate, future costs associated with biologics and the humanistic burden require policy consideration.