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Dimeric 2-(2-phenethyl)chromones from agarwood of Aquilaria filaria
Hong-Run Yang1, Pei Wang2, Fang-Zheng Liu1
1College of Pharmacy, Dali University, Dali 671003, PR China; Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province, Hainan Institute for Tropical Agricultural Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, PR China; Hainan Engineering Research Center of Agarwood, Hainan Institute for Tropical Agricultural Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan 571101, PR China.
Abstract:
Four new 2-(2-phenethyl)chromone dimers (1-4) were isolated from EtOAc extract of agarwood originating from Aquilaria filaria from Philippines. Their structures were elucidated by spectroscopic analysis (1D and 2D NMR, and HRESIMS) and comparison of the experimental and computed ECD curves. Compounds 1-4 exhibited inhibition of nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cells with IC50 values in the range from 33.94 to 57.53 μM.
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