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Fibrinolytic therapy in patients with COVID-19 and ARDS: protocol for a systematic review and meta-analysis
Felicio Savioli1,2, Lucas Ribeiro Dos Santos2, Marcio Luis Duarte2
1Critical Care Medicine, Hospital Sirio-Libanes, Sao Paulo, Brazil feasavioli@gmail.com.
Introduction:
In COVID-19-related acute respiratory distress syndrome (ARDS), the clot play a role in gas exchange abnormalities. Fibrinolytic therapy can improve alveolar ventilation by restoring blood flow. In this systematic review and meta-analysis protocol, we aim to assess the safety and efficacy of fibrinolytic therapy in such a population.
Methods:
We will perform a systematic search in MEDLINE, EMBASE, Cochrane CENTRAL and LILACS databases without language restrictions for relevant randomised controlled trials (RCTs) and quasi-RCTs. Two review authors will independently perform data extraction and quality assessments of data from included studies. In case of divergence, a third author will be contacted. The Cochrane handbook will be used for guidance. If the results are not appropriate for a meta-analysis, a descriptive analysis will be performed.
Discussion:
This systematic review and meta-analysis protocol will provide current evidence about the safety and efficacy of fibrinolytic therapy in patients with COVID-19 and ARDS. These findings will provide if fibrinolytic therapy might be an option for a desperate clinical setting, where all medical efforts have been used.
Prospero Registration Number:
PROSPERO CRD42020187482.
Ethics And Dissemination:
Ethics committee approval is not necessary. We intend to update the public registry, report any protocol amendments and publish the results in a widely accessible journal.
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