Changes in Serum Uric Acid Level in Acute Myocardial Infarction Patients

Area of Science:

• Biochemistry
• Cardiology
• Clinical Medicine

Background:

• Myocardial infarction (MI) is a critical manifestation of coronary artery disease and a leading cause of mortality.
• Biomarkers for early detection and risk stratification of MI are crucial for improving patient outcomes.
• Serum uric acid, a product of purine metabolism, has been investigated for its potential role in cardiovascular diseases.

Purpose of the Study:

• To investigate the association between serum uric acid levels and acute myocardial infarction (AMI).
• To compare serum uric acid concentrations in patients diagnosed with AMI versus healthy individuals.

Main Methods:

• A cross-sectional study involving 120 subjects (60 AMI patients and 60 healthy controls) was conducted.
• Serum uric acid levels were determined using an enzymatic colorimetric method.
• Statistical analysis, including Student's unpaired 't' test, was performed using SPSS version 21.0.

Main Results:

• The mean serum uric acid level in the AMI patient group was 6.61±2.62 mg/dL.
• The mean serum uric acid level in the control group was 5.38±1.16 mg/dL.
• Serum uric acid levels were found to be statistically significantly higher in the AMI group compared to the control group (p=0.001).

Conclusions:

• Serum uric acid is significantly elevated in patients with acute myocardial infarction.
• These findings suggest that serum uric acid may serve as a potential biomarker for AMI.
• Further research is warranted to explore the clinical utility of uric acid in MI diagnosis and management.