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Updated: Jun 25, 2026
Folding and Characterization of a Bio-responsive Robot from DNA Origami
Published on: December 3, 2015
A DNA origami nanostructure embedded with NQO1-activated prodrugs for precision drug delivery
Zhimei He1, Wenjie Xiang2, Qin Fan2
1Smart Health Big Data Analysis and Location Services Engineering Research Center of Jiangsu Province, School of Geographic and Biologic Information, Nanjing University of Posts & Telecommunications, Nanjing, 210023, P. R. China. iamjchao@njupt.edu.cn.
Abstract:
A rectangle DNA origami nanostructure equipped with doxorubicin-derived prodrugs targeting a tumor cell-specific enzyme (NQO1) is constructed. Combining the high prodrug payload of DNA origami and NQO1-activated chemotherapy, this nanosystem presents therapeutic selectivity for NQO1-overexpressing MCF-7 cells over healthy L02 cells, offering a potent strategy for precision cancer therapy.
