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Updated: Aug 15, 2025
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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
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TH17 cell heterogeneity and its role in tissue inflammation
Alexandra Schnell1,2, Dan R Littman3,4, Vijay K Kuchroo5,6
1Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.
Nature Immunology
|January 3, 2023
Summary
Interleukin-17-producing CD4+ T cells (TH17 cells) exhibit heterogeneity and plasticity. This diversity influences their roles in maintaining tissue homeostasis and driving autoimmune diseases.
Area of Science:
- Immunology
- Cell Biology
- Autoimmunity
Background:
- Interleukin-17-producing CD4+ T cells (TH17 cells) are key players in autoimmune and inflammatory diseases.
- TH17 cells also contribute to tissue homeostasis, particularly in the gut.
- Recent advances have revealed significant heterogeneity and plasticity within TH17 cell populations.
Purpose of the Study:
- To review the heterogeneity of TH17 cells in various tissues.
- To explore the functional consequences of TH17 cell heterogeneity.
- To discuss TH17 cell plasticity and its impact on understanding T cell subsets and disease roles.
Main Methods:
- Review of recent literature utilizing single-cell technologies.
- Analysis of fate mapping studies.
- Examination of data from various mutant mouse models.
Main Results:
- TH17 cell populations are diverse, with distinct states and functions.
- This heterogeneity is crucial for both maintaining tissue homeostasis and contributing to inflammation.
- TH17 cell plasticity allows for dynamic functional changes.
Conclusions:
- Understanding TH17 cell heterogeneity and plasticity is vital for comprehending their multifaceted roles.
- This knowledge can lead to novel therapeutic strategies for autoimmune and inflammatory conditions.
- Revisiting the role of TH17 cells in disease based on their plasticity is warranted.
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