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Sensory Functions of the Skin01:16

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The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
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Drug excretion involves various organs, including the liver, intestines, skin, and eyes. In the case of drugs or toxins, they can be actively secreted into bile by transporters in the hepatocyte's canalicular membrane. These substances enter the GI tract during digestion and may be reabsorbed into the body from the intestine. This process, known as enterohepatic recycling, can significantly prolong the presence and effects of a substance in the body. To interrupt this cycle, specific...
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Tactile senses encompass touch, temperature, and pain, each mediated by specific receptors. Touch receptors detect mechanical energy or pressure against the skin. Sensory fibers from these receptors enter the spinal cord and relay information to the brain stem. Here, most fibers cross over to the opposite side of the brain. The touch information then moves to the thalamus, which projects a map of the body's surface onto the somatosensory areas of the parietal lobes in the cerebral cortex.
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A Detailed Protocol for Perspiration Monitoring Using a Novel, Small, Wireless Device
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Vending-Machine-Style Skin Excretion Sensing.

Kai-Chiang Yu1, Chun-Yao Hsu1, Gurpur Rakesh D Prabhu1

  • 1Department of Chemistry, National Tsing Hua University, 101, Section 2, Kuang-Fu Road, Hsinchu300044, Taiwan.

ACS Sensors
|January 4, 2023
PubMed
Summary
This summary is machine-generated.

This study introduces a vending-machine-style platform for rapid skin metabolite analysis. The automated system uses hydrogel-assisted sampling and mass spectrometry for efficient clinical diagnostics.

Keywords:
automationhydrogelmetabolomicsroboticsskin metabolites

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Clinical Diagnostics

Background:

  • Skin metabolites hold significant potential for clinical diagnostics.
  • Current skin sampling and analysis methods are often tedious and time-consuming.

Purpose of the Study:

  • To develop an automated, vending-machine-style platform for skin metabolite sensing.
  • To streamline the process of skin metabolite sampling and analysis for clinical applications.

Main Methods:

  • Utilized a robotic arm with a hydrogel-assisted sampling probe to collect water-soluble skin metabolites.
  • Integrated the sampling probe with a high-resolution quadrupole-time-of-flight mass spectrometer for immediate analysis.
  • Developed a user-friendly interface for automated sample collection and data display.

Main Results:

  • Achieved limits of detection for arginine, citrulline, and histidine at 148, 205, and 199 nM, respectively.
  • Successfully identified various low-molecular-weight metabolites from human skin using high-resolution mass spectrometry.
  • Demonstrated an automated workflow initiated by user interaction, similar to a vending machine.

Conclusions:

  • The developed platform offers a rapid and automated approach to skin metabolite analysis.
  • This technology has the potential to significantly improve the efficiency of clinical diagnostics based on skin metabolites.
  • The system's reliance on low-cost components makes it a potentially accessible diagnostic tool.