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[Cryptococcoma of the adrenal gland].

H R Schurter¹, C Hedinger

¹Institut für Pathologie der Universität Zürich.

Schweizerische Medizinische Wochenschrift

|August 4, 1987

Summary

A patient with cryptococcal meningoencephalitis developed complications including hydrocephalus and intraventricular cerebral hemorrhage. An adrenal cryptococcoma was found at autopsy, presumed to be the source of recurrent cryptococcosis.

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Area of Science:

Neurology
Infectious Diseases
Pathology

Background:

Cryptococcal meningoencephalitis is a serious fungal infection of the brain and meninges.
Complications can include hydrocephalus, requiring surgical intervention.
Anticoagulation therapy poses risks for patients with intracranial pathology.

Observation:

A 49-year-old man presented with cryptococcal meningoencephalitis.
He developed hydrocephalus requiring a ventriculo-peritoneal shunt.
The patient later died from intraventricular cerebral hemorrhage while on anticoagulation therapy.

Findings:

Blood cultures revealed Cryptococcus neoformans shortly before death.
Autopsy confirmed cerebral hemorrhage as the cause of death.
An incidental adrenal gland cryptococcoma was discovered, presumed to be the source of disseminated disease.

Implications:

Adrenal cryptococcomas can serve as a reservoir for recurrent cryptococcosis.
This case highlights the importance of considering fungal infections in immunocompromised patients.
Understanding cryptococcosis pathogenesis is crucial for managing complex neurological cases.

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