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Related Concept Videos

Necrosis01:16

Necrosis

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Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
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Related Experiment Video

Updated: Aug 15, 2025

Author Spotlight: Enhancing Understanding and Treatment Strategies with the NEC-on-a-Chip Model
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Author Spotlight: Enhancing Understanding and Treatment Strategies with the NEC-on-a-Chip Model

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Models of necrotizing enterocolitis.

Carla M Lopez1, Maame Efua S Sampah1, Johannes W Duess1

  • 1Division of Pediatric Surgery and the Department of Surgery at the Johns Hopkins University, Bloomberg Children's Center, The Johns Hopkins Hospital, Room 7323, 1800 Orleans Street, Baltimore, MD 21287, USA.

Seminars in Perinatology
|January 4, 2023
PubMed
Summary

Necrotizing enterocolitis (NEC) is a severe infant disease. This review evaluates animal models for studying NEC pathogenesis, focusing on host-microbe interactions and the role of Toll-like Receptor 4 (TLR4).

Keywords:
Models of necrotizing enterocolitisNECNecrotizing enterocolitis

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Area of Science:

  • Neonatal research
  • Gastroenterology
  • Immunology

Background:

  • Necrotizing enterocolitis (NEC) is a critical gastrointestinal disease in premature infants, with high mortality and limited therapeutic advances.
  • Understanding NEC pathogenesis is crucial for developing effective treatments, necessitating translational research models.

Conclusions:

  • A variety of animal models are available for NEC research, each with specific applications and limitations.
  • Selecting the appropriate model is critical for advancing our understanding of NEC pathogenesis and for developing new therapies.
  • This review aims to clarify the landscape of NEC models to facilitate research in this field.