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The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
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Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
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Imaging Studies I: Kidney, Ureter, and Bladder Studies01:28

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Kidney, Ureter, and Bladder (KUB) StudiesKidney, Ureter, and Bladder (KUB) studies are standard diagnostic imaging procedures used to assess the anatomy of the urinary system. They are commonly utilized for patients experiencing abdominal pain or urinary symptoms. By using a simple X-ray of the abdomen, KUB studies can reveal structural and pathological abnormalities within the kidneys, ureters, and bladder. These studies are particularly valuable in diagnosing kidney stones, urinary...
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Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

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A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
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Anatomy of the Genitourinary System II: Bladder and Urethra01:19

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The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...
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Imaging Studies VI: Voiding Cystourethrography and Cystography01:22

Imaging Studies VI: Voiding Cystourethrography and Cystography

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Voiding Cystourethrography (VCUG) and Cystography are specialized radiographic procedures used to examine the structure and function of the bladder and urethra.Voiding Cystourethrography (VCUG)A Voiding Cystourethrogram (VCUG) is a diagnostic imaging procedure that assesses the anatomy and function of the lower urinary tract. It focuses on the bladder, bladder neck, and urethra, helping detect abnormalities such as vesicoureteral reflux (VUR)—the backward or reverse flow of urine into the...
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Cohort profile: Bladder Cancer Data Base Sweden (BladderBaSe) 2.0.

Christel Häggström1,2, Oskar Hagberg3, Truls Gårdmark4

  • 1Department of Surgical Sciences, Uppsala University, Uppsala, Sweden christel.haggstrom@umu.se.

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|January 5, 2023
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Summary

The BladderBaSe 2.0 database expands research on bladder, upper tract urothelial carcinoma (UTUC), and urethral cancers, analyzing incidence, outcomes, and survival. It includes over 53,000 cancer patients and 275,000 controls for comprehensive health economic studies.

Keywords:
Adult surgeryAdult urologyRadiation oncologyUrological tumours

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Area of Science:

  • Urology
  • Oncology
  • Epidemiology

Background:

  • The BladderBaSe 2.0 database is an expansion of previous BladderBaSe studies.
  • It focuses on bladder cancer, upper tract urothelial carcinoma (UTUC), and urethral carcinoma.
  • The database aims to study incidence, treatment outcomes, survival, and health economics.

Purpose of the Study:

  • To expand BladderBaSe studies on cancer of the urinary bladder, UTUC, and urethral carcinoma.
  • To analyze incidence, treatment outcomes, side effects, survival, and health economic aspects.
  • To provide a comprehensive dataset for epidemiological and clinical research in urothelial cancers.

Main Methods:

  • Construction of BladderBaSe 2.0 database.
  • Inclusion of 53,298 patients with bladder cancer (1997-2019).
  • Inclusion of 961 renal pelvis UTUC, 792 ureter UTUC, and 146 urethral carcinoma patients (2015-2019).
  • Inclusion of 275,816 cancer-free reference participants matched by sex, age, and county.

Main Results:

  • Previous BladderBaSe studies investigated survival trends, prognostic factors (gender, socioeconomic status, tumor aggressiveness, hospital volume), and complications after radical cystectomy.
  • Studies compared survival after radical cystectomy versus radiotherapy.
  • Identified risk factors for complications like thromboembolism, ureteroenterostomy strictures, and incisional hernia.

Conclusions:

  • BladderBaSe 2.0 provides a robust platform for extensive research into urothelial cancers.
  • Ongoing and future research will explore gender-specific detection delays, outcomes of non-muscle invasive bladder cancer treatment, comparative effectiveness of open vs. robot-assisted radical cystectomy, UTUC recurrence risks, and suicide risk.
  • The project actively seeks national and international collaborations.