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Related Concept Videos

Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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Parkinson's Disease: Treatment01:24

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Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
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The Rossy Progressive Supranuclear Palsy Centre: Creation and Initial Experience.

Blas Couto1, Susan Fox1,2, Maria Carmela Tartaglia1,2,3,4

  • 1Edmond J. Safra Program in Parkinson's Disease, Rossy Progressive Supranuclear Palsy Centre and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, Ontario, Canada.

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
|January 5, 2023
PubMed
Summary

The Rossy PSP Centre in Canada advances research in progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS). Initial data show typical patient demographics and symptom presentation, informing future diagnosis and treatment strategies.

Keywords:
BiomarkersCorticobasal degenerationMovement disordersNeurodegenerative diseasesProgressive Supranuclear Palsy

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Area of Science:

  • Neuroscience
  • Clinical Neurology
  • Rare Diseases

Background:

  • Progressive Supranuclear Palsy (PSP) and Corticobasal Syndrome (CBS) are rare neurodegenerative disorders.
  • There is a need for dedicated research programs to understand and manage these conditions.
  • The Rossy PSP Centre was established to address this need in Canada.

Purpose of the Study:

  • To establish and describe the initial phase of a clinical research program for PSP and CBS in Canada.
  • To detail the data acquisition tools and methodologies employed.
  • To report preliminary findings from the program's early experience.

Main Methods:

  • Collected extensive demographic and longitudinal clinical data every six months.
  • Acquired biofluids for biobanking and genetic analysis.
  • Enrolled patients in neuroimaging protocols and facilitated brain donation with standardized processing.

Main Results:

  • Screened 132 patients (91 PSP, 19 CBS) between Oct 2019 and Dec 2021.
  • Identified key onset symptoms: postural instability/falls (45%), cognitive-behavioral changes (22%).
  • Richardson syndrome was the predominant PSP phenotype (82%); symptomatic treatments offered limited benefit.

Conclusions:

  • The Rossy PSP Centre is operational, facilitating deep phenotyping for PSP and related tauopathies.
  • Preliminary data align with expected cohort characteristics and treatment responses.
  • Future research will focus on early diagnosis, biomarker development, and clinical trial enrollment.