Related Experiment Video
Updated: Aug 15, 2025
Inducing Polyp Bail-out in Coral Colonies to Obtain Individualized Micropropagates for Laboratory Experimental Use
Published on: April 28, 2022
Can a Solitary Juvenile Polyp Be Regarded as a Nonmalignant Polyp?
Kumiko Fukami1, Makoto Furihata1, Shintaro Yano1
1Department of Gastroenterology, Juntendo University Urayasu Hospital, Urayasu-shi, Chiba, Japan.
Insights
Juvenile polyps (JPs) are typically benign colorectal lesions in children. This case highlights a rare instance of signet ring cell carcinoma, a rare colorectal cancer, developing within a solitary juvenile polyp.
Area of Science:
- Gastroenterology and Oncology
- Colorectal Cancer Research
Background:
- Juvenile polyps (JPs) are common, benign hamartomatous lesions primarily affecting the pediatric colorectum.
- Solitary JPs have a minimal risk of malignant transformation.
- Signet ring cell carcinoma is a rare colorectal cancer subtype, often diagnosed at advanced stages in younger individuals.
Observation:
- A rare case of signet ring cell carcinoma was identified within a solitary juvenile polyp.
- This presentation is unusual given the typical benign nature of juvenile polyps.
Findings:
- The patient's signet ring cell carcinoma was successfully treated with endoscopic mucosal resection.
- This case demonstrates that malignancy can occur in solitary JPs, albeit rarely.
Implications:
- Highlights the importance of considering rare malignant transformations even in seemingly benign lesions like JPs.
- Suggests endoscopic mucosal resection as a viable treatment option for localized signet ring cell carcinoma within JPs.
- Contributes to understanding the diverse clinical presentations of colorectal cancer in younger populations.
Abstract:
Juvenile polyps (JPs) are common, developing mostly as solitary, hamartomatous lesions in the colorectum, and principally affect pediatric patients. Solitary JPs are recognized as benign, with a negligible malignant transformation rate. Primary signet ring cell carcinoma is a rare type of colorectal cancer (0.1%-2.6%) that presents mostly at an advanced stage in younger patients and affects the right-sided colon, with extensive lymphatic invasion and peritoneal dissemination, resulting in a poorer prognosis compared with conventional colorectal cancer. We report a rare case of signet ring cell carcinoma in a solitary JP treated with endoscopic mucosal resection.
