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Published on: June 10, 2021
Visible light driven multicomponent synthesis of difluoroamidosulfonyl quinoline derivatives
Haiwei Ye1, Liping Zhou1, Yunhua Chen1
1Chemical Pharmaceutical Research Institute, Taizhou Vocational & Technical College, Taizhou, 318000, P.R. China. yehw@tzvtc.edu.cn.
Abstract:
A visible-light-induced photocatalyst-free three-component radical tandem cyclization of N-propargylamine and N-allylbromodifluoroacetamides with the insertion of sulfur dioxide has been developed. Diverse difluoroamidosulfonylated quinolines are obtained in moderate to good yields. This protocol features broad functional group tolerance and high regioselectivity. Moreover, mechanistic studies reveal the involvement of the radical pathway and the formation of an electron donor-acceptor (EDA) complex in this reaction.
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