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The The Impact of Surgical Revascularization on Cardiac Function and Mitral Regurgitation in Patients with Coronary
Hani Mufti1, Mouaz Bamsallm2, Abdulaziz Almalki3
1Department of Cardiac Sciences, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Jeddah, Saudi Arabia. drhanimufti@yahoo.com.
Insights
Coronary artery bypass grafting (CABG) surgery can improve left ventricular ejection fraction (LVEF) and ischemic mitral regurgitation (IMR) without direct mitral valve intervention. This study shows CABG is safe and effective for improving cardiac function in patients with coronary artery disease.
Area of Science:
- Cardiology
- Cardiac Surgery
- Echocardiography
Background:
- Ischemic heart disease is a leading global cause of mortality.
- Coronary artery bypass grafting (CABG) is the most common cardiac surgical procedure.
- CABG may positively impact left ventricular ejection fraction (LVEF) and ischemic mitral regurgitation (IMR).
Purpose of the Study:
- To evaluate the effects of CABG on LVEF and IMR.
- To assess changes in cardiac function and mitral regurgitation post-CABG in a specific patient population.
Main Methods:
- Retrospective review of 298 patients undergoing isolated CABG.
- Analysis of pre- and postoperative echocardiography data.
- Evaluation of changes in LVEF and IMR.
Main Results:
- No significant change in LVEF post-CABG (median 51% pre-op vs. 50.3-53.1% post-op).
- No progression to severe IMR; only 2.7% developed moderate-to-severe MR.
- Low in-hospital mortality rate of 0.7%.
Conclusions:
- CABG alone is sufficient for patients with moderate IMR and coronary artery disease.
- CABG does not worsen LVEF or IMR progression.
- Complete revascularization may aid ventricular recovery and improve IMR.
Introduction:
Ischemic heart disease is the most common cause of death worldwide. Coronary artery bypass grafting (CABG) is the most performed cardiac surgical procedure. Studies have shown that CABG can have a beneficial effect on left ventricular ejection fraction (LVEF) and ischemic mitral regurgitation (IMR) without intervention on the mitral valve. This study aims to assess changes in LVEF and IMR after CABG in our population.
Methods:
We retrospectively reviewed charts of patients who underwent only CABG at King Faisal Cardiac Center in Jeddah between January 2016 and December 2019 (N = 298). Pre- and postoperative echocardiography data were evaluated. Changes in cardiac function and mitral regurgitation were analyzed.
Results:
CABG was performed on 298 patients. The median age was 61 years (interquartile range (IQR)= 54-68), and 78.5% of the patients were male. The median body mass index was slightly higher in females (32.9 vs. 28.6 kg/m2, P = 0.089). Approximately 81% of patients had diabetes and hypertension, but only 24% were active smokers. The median time between pre- and postoperative echocardiography was 8 months (IQR= 3-17). The median preoperative LVEF was 51% (IQR= 44.1-57.9), and 75% of patients had normal-to-mild MR. The median postoperative EF was not different among patients who underwent echocardiography within or after 6 months (53.1% and 50.3%, respectively, P = 0.454). None of the patients progressed to severe MR after surgery, and only 2.7% had moderate-to-severe MR at follow up. Postoperative in-hospital mortality was 0.7%.
Conclusion:
Based on international guidelines and the best evidence, surgical revascularization is sufficient for patients with coronary artery disease (CAD) with moderate IMR and is not associated with LVEF worsening or MR progression. Complete revascularization might have an influence on ventricular recovery that might improve or stabilize IMR. Our results are consistent with larger studies reporting very low postoperative mortality of this high-risk patient group.
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