Related Experiment Video
Updated: Aug 15, 2025

Generating Genetically Modified Plasmodium berghei Sporozoites
Published on: May 5, 2023
Mosquito bypassers: infectious sporozoites grown in vitro
1Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; School of Biological Sciences, Nanyang Technological University, Singapore; A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore.
Abstract:
The whole-sporozoite-based vaccine approach has been limited by the difficulty of mass production of infectious sporozoites from infected mosquitoes. Eappen et al. describe a method for producing a large quantity of sporozoites in vitro, which opens new areas of investigations in sporozoite biology and large-scale sporozoite production for vaccine development.

