Two-Step Skincare Regimen Addressing Aging in Three Unique Geographic Locations: A Prospective, Multi-Center,...

Area of Science:

• Dermatology and cosmetic science.
• Environmental impacts on skin health.

Background:

• Extrinsic factors like solar radiation and pollution accelerate facial skin aging.
• Hyperpigmentation and photodamage are common concerns in women exposed to environmental stressors.
• A novel 2-step skincare regimen was investigated for its efficacy and tolerability.

Purpose of the Study:

• To evaluate the efficacy of a vitamin C antioxidant serum (VCAS) and a 100% mineral tinted sunscreen moisturizer (TSM) in improving facial skin aging.
• To assess the tolerability and subject perception of this 2-step regimen.
• To determine the regimen's effectiveness in women with hyperpigmented and photodamaged skin exposed to diverse environmental conditions.

Main Methods:

• An IRB-approved, multi-center, prospective, open-label study was conducted over 12 weeks.
• Thirty-six women (35-60 years, Fitzpatrick Skin Types I-V) with moderate to severe hyperpigmentation and photodamage participated.
• Participants applied VCAS twice daily and TSM with reapplication daily; assessments included clinical grading, photography, and self-questionnaires.

Main Results:

• Statistically significant improvements in clinical efficacy parameters were observed at weeks 4, 8, and 12.
• Photodamage improved by up to 19.1%, and skin clarity/brightness by up to 24.5% over 12 weeks.
• Clinically significant improvements in forehead and cheek lines were noted, with good product tolerability and perception.

Conclusions:

• The 2-step skincare regimen, combining VCAS and TSM, is well-tolerated and effective.
• The regimen successfully improved extrinsic signs of facial aging caused by solar radiation and air pollution.
• This skincare approach offers a viable solution for managing environmentally induced skin aging concerns.