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Lung Capacity

Lung Capacity

The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.

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Related Experiment Video

Updated: Aug 15, 2025

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease

Published on: April 12, 2021

Empowering human lung development.

Jiao Li¹, Nan Tang²

¹National Institute of Biological Sciences, Beijing, 102206, China.

|January 7, 2023

Summary

This summary is machine-generated.

Researchers created a multiomic cell atlas of human embryonic lungs and a novel organoid system. These advancements offer new insights into human lung development.

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Procedure for Lung Engineering

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Last Updated: Aug 15, 2025

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease

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Published on: April 12, 2021

Establishing Human Lung Organoids and Proximal Differentiation to Generate Mature Airway Organoids

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Published on: March 23, 2022

Procedure for Lung Engineering

Procedure for Lung Engineering

Published on: March 8, 2011

Area of Science:

Developmental Biology
Genomics
Cell Biology

Background:

Understanding human lung development is crucial for addressing congenital lung diseases.
Previous research has been limited by the lack of detailed cellular and molecular data during human lung formation.

Purpose of the Study:

To generate a comprehensive multiomic cell atlas of the embryonic human lung.
To establish a functional in vitro model for studying human lung development using tip progenitor cells.

Main Methods:

Single-cell RNA sequencing and other omics technologies were employed to create the cell atlas.
Human embryonic lung tip progenitor cells were cultured to establish an organoid system.

Main Results:

The multiomic atlas provides unprecedented resolution of cell types and states during human lung development.
The organoid system successfully recapitulates key aspects of human lung branching morphogenesis and differentiation.

Conclusions:

These studies represent significant progress in understanding the molecular mechanisms of human lung development.
The developed resources will accelerate research into lung diseases and inform therapeutic strategies.