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[Lattice structure antacids and antacid mixtures].

S E Miederer1, C Schmidt

  • 1Medizinische Klinik des Ev. Johannes Krankenhauses Bielefeld.

Zeitschrift Fur Gastroenterologie
|August 1, 1987
PubMed
Summary

Aluminum-magnesium hydroxide antacids effectively heal gastric and duodenal ulcers, reducing the required daily dosage. However, long-term use requires critical evaluation due to potential mineral metabolism changes.

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Area of Science:

  • Gastroenterology and Pharmacology
  • Drug Efficacy and Safety Studies

Background:

  • The clinical significance of antacid neutralizing capacity in ulcer healing has diminished.
  • Aluminum-magnesium hydroxide antacid mixtures demonstrate efficacy comparable to H2 receptor antagonists for ulcer healing.

Purpose of the Study:

  • To evaluate the efficacy of lattice-structured antacids, such as Magaldrate, in healing gastric and duodenal ulcers.
  • To compare the effectiveness of Magaldrate with Ranitidine.
  • To assess the need for critical evaluation of maintenance therapy with antacids.

Main Methods:

  • Clinical investigations comparing antacid mixtures and lattice-structured antacids against H2 receptor antagonists and placebo.
  • Studies assessing ulcer healing rates with specific antacid dosages (100-150 mmol/day and 100-350 mmol/day).
  • Analysis of mineral metabolism changes associated with aluminum-magnesium hydroxide antacids.

Main Results:

  • Aluminum-magnesium hydroxide antacids healed gastric and duodenal ulcers effectively, allowing for reduced daily dosages.
  • Lattice-structured antacids (Magaldrate) showed efficacy comparable to Ranitidine (150 mg b.d.) in ulcer healing.
  • Significant changes in mineral metabolism were observed with very low dosages of aluminum-magnesium hydroxide antacids.

Conclusions:

  • Antacid compounds, particularly aluminum-magnesium hydroxide formulations, are effective in healing gastric and duodenal ulcers.
  • Maintenance therapy with these antacids warrants critical evaluation due to insufficient data and potential adverse effects on mineral metabolism.
  • Even in patients with normal kidney function, low-dose aluminum-magnesium hydroxide antacids can impact mineral metabolism.

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