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Repurposing Drugs in Small Animal Oncology.

Antonio Giuliano1,2, Rodrigo S Horta3, Rafael A M Vieira4

  • 1CityU Veterinary Medical Centre, City University of Hong Kong, Kowloon, Hong Kong.

Animals : an Open Access Journal From MDPI
|January 8, 2023
PubMed
Summary

Drug repurposing in oncology uses existing non-cancer drugs to treat cancer, offering known safety and affordability. This review explores benefits, challenges, and potential repurposed drugs for veterinary oncology in dogs and cats.

Keywords:
oncologyrepurposing drugssmall animal oncology

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Area of Science:

  • Veterinary Medicine
  • Oncology
  • Pharmacology

Background:

  • Drug repurposing involves using approved non-oncological drugs for cancer treatment.
  • Repurposed drugs offer advantages like known safety profiles, pharmacokinetics, and lower costs.
  • This approach is gaining traction in human oncology, with ongoing research into clinical efficacy.

Purpose of the Study:

  • To review the benefits and challenges of repurposed anti-cancer drugs in veterinary oncology.
  • To discuss existing studies on repurposed drugs in small animal oncology.
  • To suggest potential drugs for future clinical investigation in canine and feline cancer treatment.

Main Methods:

  • Literature review of in vivo, in vitro, and clinical studies on repurposed anti-cancer drugs.
  • Analysis of published research in veterinary oncology, specifically for small animals.
  • Identification and discussion of drugs with potential anti-cancer activity in dogs and cats.

Main Results:

  • Repurposed drugs present known safety and pharmacokinetic profiles, making them cost-effective alternatives.
  • While promising results exist from preclinical and some clinical studies in humans, definitive clinical benefit is often unknown.
  • The application of drug repurposing in veterinary oncology is nascent, with limited published data.

Conclusions:

  • Drug repurposing holds significant potential for affordable and accessible cancer treatment in veterinary oncology.
  • Further research and clinical trials are needed to establish the efficacy and safety of repurposed drugs in dogs and cats.
  • Identifying and investigating novel repurposed agents could expand therapeutic options for animal cancer patients.