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Genomic and Transcriptional Profiling of Chinese Melanoma Patients Enhanced Potentially Druggable Targets: A

Yue Li1, Baoming Wang2, Chunyang Wang2

  • 1Harbin Medical University Cancer Hospital, Harbin 150040, China.

Cancers
|January 8, 2023
PubMed
Abstract

Insights

This study analyzed actionable targets in Chinese melanoma patients using DNA and RNA sequencing. Sequential sequencing identified druggable targets in 78% of patients, improving clinical benefit.

Area of Science:

  • Oncology
  • Genomics
  • Precision Medicine

Background:

  • Melanoma research predominantly focuses on Caucasian populations, with limited data on Asian patients.
  • Previous studies indicated a lower druggable target rate (40%) in Asian melanoma patients compared to Caucasians.
  • Further investigation is needed to accurately assess the actionable landscape in Asian melanoma.

Purpose of the Study:

  • To systematically analyze the actionable genomic alterations in the largest cohort of Chinese melanoma patients.
  • To determine the utility of sequential DNA and RNA next-generation sequencing (NGS) for identifying druggable targets.
  • To refine the understanding of melanoma's actionable landscape in an Asian population.

Main Methods:

  • 469 Chinese melanoma patients underwent sequential DNA and RNA next-generation sequencing (NGS).
  • Genomic alterations were identified, and potentially actionable targets were investigated using OncoKB.
  • RNA-NGS was used to verify and identify fusions missed by DNA-NGS.

Main Results:

  • DNA-NGS identified potential druggable targets in 75% of patients, exceeding previous Asian study findings.
  • NRG1 fusions were identified in melanoma for the first time.
  • RNA-NGS analysis identified actionable targets in an additional 11.7% of previously undruggable cases, increasing the overall druggable proportion to 78%.

Conclusions:

  • Sequential DNA and RNA sequencing is crucial for maximizing the identification of actionable targets in melanoma.
  • This comprehensive analysis of the largest Asian cohort provides essential insights into the actionable landscape of melanoma.
  • Integrating RNA-NGS significantly enhances the clinical benefit by uncovering druggable targets in a larger proportion of melanoma patients.
Keywords:
DNA-NGSRNA-NGSmelanomasequencetarget

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