Related Experiment Video
Updated: Aug 15, 2025
Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation
Published on: July 23, 2012
Emerging Role of MicroRNA-30c in Neurological Disorders
1Department of Neurosurgery, Pennsylvania State University College of Medicine, 500 University Drive, BMR, Hershey, PA 17033, USA.
Abstract:
MicroRNAs (miRNAs or miRs) are a class of small non-coding RNAs that negatively regulate the expression of target genes by interacting with 3' untranslated regions of target mRNAs to induce mRNA degradation and translational repression. The miR-30 family members are involved in the development of many tissues and organs and participate in the pathogenesis of human diseases. As a key member of the miR-30 family, miR-30c has been implicated in neurological disorders such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, and stroke. Mechanistically, miR-30c may act as a multi-functional regulator of different pathogenic processes such as autophagy, apoptosis, endoplasmic reticulum stress, inflammation, oxidative stress, thrombosis, and neurovascular function, thereby contributing to different disease states. Here, we review and discuss the biogenesis, gene regulation, and the role and mechanisms of action of miR-30c in several neurological disorders and therapeutic potential in clinics.
Insights
MicroRNAs (miRNAs) regulate gene expression. This review focuses on miR-30c, a key miRNA involved in neurological disorders like Alzheimer's and Parkinson's disease, and its therapeutic potential.
Area of Science:
- Molecular Biology
- Neuroscience
- Genetics
Background:
- MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by targeting mRNA.
- The miR-30 family plays a role in tissue development and disease pathogenesis.
- miR-30c is specifically implicated in various neurological disorders.
Purpose of the Study:
- To review the biogenesis and gene regulation of miR-30c.
- To discuss the role and mechanisms of miR-30c in neurological disorders.
- To explore the therapeutic potential of miR-30c in clinical settings.
Main Methods:
- Literature review of studies on miR-30c.
- Analysis of miR-30c's involvement in pathogenic processes.
- Evaluation of miR-30c's therapeutic applications.
Main Results:
- miR-30c negatively regulates gene expression.
- miR-30c is implicated in Alzheimer's disease, Parkinson's disease, multiple sclerosis, and stroke.
- miR-30c modulates autophagy, apoptosis, ER stress, inflammation, oxidative stress, thrombosis, and neurovascular function.
Conclusions:
- miR-30c is a multi-functional regulator in neurological disorders.
- Understanding miR-30c mechanisms offers therapeutic avenues.
- miR-30c holds promise for treating neurological conditions.
More Related Videos
09:40Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
Published on: October 4, 2019
07:55Harnessing the Power of MicroRNA Cargoes in Small Extracellular Vesicles Released from Fresh-Frozen Human Brain Sections
Published on: November 8, 2024
