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Updated: Aug 15, 2025

Identifying Amino Acid Overproducers Using Rare-Codon-Rich Markers
Published on: June 24, 2019
Genetic Code Expansion: Another Solution to Codon Assignments
1Laboratory for Nonnatural Amino Acid Technology, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan.
This Special Issue highlights advances in genetic code expansion, focusing on the site-specific incorporation of noncanonical amino acids (ncAAs) into proteins for novel applications.
Area of Science:
- Biochemistry
- Molecular Biology
- Synthetic Biology
Background:
- Genetic code expansion enables the site-specific incorporation of noncanonical amino acids (ncAAs) into proteins.
- This technology expands the functional repertoire of proteins beyond the 20 standard amino acids.
Discussion:
- Recent advancements in genetic code expansion are presented.
- Focus on methodologies for site-specific incorporation of ncAAs.
- Applications of ncAAs in protein engineering and biotechnology are explored.
Key Insights:
- Novel ncAAs and improved incorporation strategies are detailed.
- Enhanced protein functionality and novel biomaterials are demonstrated.
- The potential of ncAAs in therapeutic development is highlighted.
Outlook:
- Future directions in genetic code expansion research.
- Expanding the scope of ncAAs and their applications.
- Overcoming challenges in large-scale production and in vivo implementation.
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