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Related Concept Videos

Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

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Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
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Thermosensation01:43

Thermosensation

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Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
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Sensory Functions of the Skin01:16

Sensory Functions of the Skin

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The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
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G-Protein Gated Ion Channels01:21

G-Protein Gated Ion Channels

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GPCRs are primarily responsible for our sense of smell, taste, and vision.  The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
Sensory...
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Non-gated Ion Channels01:24

Non-gated Ion Channels

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Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
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Ligand-gated Ion Channels01:19

Ligand-gated Ion Channels

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Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that...
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Related Experiment Video

Updated: Aug 15, 2025

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors
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Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors

Published on: September 27, 2019

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Transient Receptor Potential Channels and Itch.

Omar Mahmoud1, Georgia Biazus Soares1, Gil Yosipovitch1

  • 1Dr. Philip Frost Department of Dermatology and Cutaneous Surgery, Miami Itch Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

International Journal of Molecular Sciences
|January 8, 2023
PubMed
Summary

Transient Receptor Potential (TRP) channels in the skin are key to itch and pain. Emerging TRP channel-targeting treatments show promise for itch relief, but more research is needed.

Keywords:
TRP channelTRPATRPCTRPMTRPVagonistantagonistitchpruritustransient receptor potential channel

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Controllable Ion Channel Expression through Inducible Transient Transfection
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Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
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Related Experiment Videos

Last Updated: Aug 15, 2025

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors
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Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors

Published on: September 27, 2019

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Controllable Ion Channel Expression through Inducible Transient Transfection
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Controllable Ion Channel Expression through Inducible Transient Transfection

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Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
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Area of Science:

  • Dermatology and Molecular Physiology
  • Neuroscience and Sensory Biology

Background:

  • Transient Receptor Potential (TRP) channels are critical sensory molecules in the skin.
  • These channels mediate pathways for itch, pain, and inflammation.

Purpose of the Study:

  • To review the physiology of TRP channels in itch.
  • To explore their role in acute and chronic itch conditions.
  • To examine emerging TRP channel-targeting anti-pruritic treatments.

Main Methods:

  • Literature review of TRP channel physiology and function.
  • Analysis of small molecule and topical agents targeting TRP channels.
  • Discussion of clinical trial progress and genetic polymorphism considerations.

Main Results:

  • TRP channels significantly modulate itch sensation and contribute to itch pathophysiology.
  • Several TRP channel targets (TRPV1, TRPV3, TRPA1, TRPM8) are being investigated for anti-pruritic therapies.
  • Some TRP channel-targeting treatments are advancing into clinical trials.

Conclusions:

  • TRP channels are central to understanding and treating itch.
  • Emerging TRP channel-based therapies offer potential for managing pruritus.
  • Further studies are required to establish the safety and efficacy of these treatments.