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Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids
Published on: August 11, 2017
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Bioprinting Technologies and Bioinks for Vascular Model Establishment
Zhiyuan Kong1, Xiaohong Wang1,2
1Center of 3D Printing & Organ Manufacturing, School of Intelligent Medicine, China Medical University (CMU), No. 77 Puhe Road, Shenyang North New Area, Shenyang 110122, China.
International Journal of Molecular Sciences
|January 8, 2023
Summary
This review covers advances in 3D bioprinting for creating vascular networks, focusing on techniques like coaxial printing for small-diameter blood vessels and microvessels. These methods aim to overcome limitations in current vascularization strategies for tissue engineering.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Vascular Tissue Engineering
Background:
- Large artery defects are treatable with synthetic grafts, but small-diameter blood vessels and microvessels pose significant challenges.
- Current vascularization strategies include spontaneous angiogenesis, pre-constructed vascular channels, and 3D bioprinting of cell-laden hydrogels.
- Developing complex, multi-scale vascular networks remains a critical hurdle in tissue engineering and regenerative medicine.
Purpose of the Study:
- To review the latest advancements in 3D bioprinting for creating vascularized tissues and organs.
- To highlight novel printing techniques and bioink research for promoting angiogenesis.
- To address the challenges in fabricating small-diameter and microvessel networks.
Main Methods:
- Review of recent literature on 3D bioprinting technologies for vascular applications.
- Discussion of techniques such as coaxial printing, freeform reversible embedded in suspended hydrogel (FLASH) printing, and acoustic-assisted printing.
- Exploration of bioinks designed to support and promote angiogenesis.
Main Results:
- 3D bioprinting offers high-precision control for fabricating hierarchical vascular networks.
- Advanced techniques like coaxial and FLASH printing show promise for creating complex vascular structures.
- Ongoing research focuses on bioinks that enhance cell viability and promote vascularization.
Conclusions:
- 3D bioprinting technologies are rapidly advancing the field of vascular tissue engineering.
- Novel printing methods and bioinks are crucial for overcoming limitations in small-diameter vessel fabrication.
- These innovations hold significant potential for creating functional vascularized tissues and organs.
