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Sex Differences in Salt Appetite: Perspectives from Animal Models and Human Studies.
Jessica Santollo1, Derek Daniels2, Micah Leshem3
1Department of Biology, University of Kentucky, Lexington, KY 40506, USA.
Nutrients
|January 8, 2023
Summary
Sex differences influence sodium intake, impacting body fluid balance. This review synthesizes research on these variations in animals and humans, exploring physiological and behavioral mechanisms.
Area of Science:
- Physiology
- Neuroendocrinology
- Behavioral Science
Background:
- Salt (sodium chloride) ingestion is a fundamental physiological need for animals and humans.
- Most research on sodium intake has focused on male rodents, with limited data on sex differences.
- Understanding sex-based variations in sodium intake is crucial for human health, as dietary salt is consumed daily.
Conclusions:
- Sex profoundly influences sodium intake and body fluid regulation.
- Further research is needed to understand the generalizability of rodent findings to humans.
- Investigating sex-specific mechanisms is essential for addressing health implications of sodium consumption.
