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Bio-Inspired Micromachined Volumetric Flow Sensor with a Big Dynamic Range for Intravenous Systems.

Lansheng Zhang1, Yingchen Yang2, Georgios A Bertos3,4,5

  • 1ZJU-UIUC Institute, International Campus, Zhejiang University, Haining 314400, China.

Sensors (Basel, Switzerland)
|January 8, 2023
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Summary

This study presents a novel micromachined volumetric flow sensor for intravenous infusion systems. The sensor achieves precise, real-time drug delivery monitoring with a wide dynamic range, enhancing patient safety.

Keywords:
big dynamic rangehaircellintravenous infusionpiezoresistorvolumetric flow sensor

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Area of Science:

  • Biomedical Engineering
  • Microsystems Technology
  • Fluid Dynamics

Background:

  • Real-time monitoring of intravenous drug delivery is crucial for preventing dosage errors and patient harm.
  • Existing infusion systems require precise control over low flow rates and a broad dynamic range for personalized medicine administration.

Purpose of the Study:

  • To develop a bio-inspired, micromachined volumetric flow sensor for accurate monitoring in intravenous infusion systems.
  • To achieve a large dynamic range in flow rate detection for versatile drug delivery applications.

Main Methods:

  • Integration of two sensing units with differing sensitivities on a single silicon die.
  • Application of a parylene coating for waterproofing and biocompatibility.
  • Development of a novel packaging scheme to embed the sensor within a flow channel.

Main Results:

  • The sensor accurately detects volumetric flow rates as low as 2 mL/h.
  • The sensor demonstrates a wide dynamic range, functioning effectively from 2 mL/h to 200 mL/h.
  • Performance exceeded that of two commercial sensors in low-flow detection.

Conclusions:

  • The developed micromachined sensor offers high sensitivity, low cost, and a small footprint, making it ideal for intravenous applications.
  • This technology promises improved safety and efficacy in drug delivery through precise real-time monitoring.