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Related Experiment Video

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Defining left ventricular remodeling using lean body mass allometry: a UK Biobank study.

Bruna Gomes1,2,3,4, Kristofer Hedman5,6,7,8, Tatiana Kuznetsova9

  • 1Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 94304, USA. bgomes@stanford.edu.

European Journal of Applied Physiology
|January 8, 2023
PubMed
Summary

This study validates lean body mass (LBM)-based allometric coefficients for scaling cardiac parameters, improving the classification of ventricular remodeling geometric patterns. A new index of left ventricular concentricity (LVC) is independent of volume and LBM.

Keywords:
AdiposityAllometryBody compositionLV hypertrophyObesityScalingVentricular remodelingVisceral fat

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Area of Science:

  • Cardiology
  • Biomedical Engineering
  • Physiology

Background:

  • Ventricular remodeling is assessed using indexed left ventricular mass (LVM), end-diastolic volume (LVEDV), and concentricity, often via mass-to-volume ratio (MVR).
  • Accurate scaling of these parameters is crucial for classifying geometric patterns of ventricular remodeling.

Purpose of the Study:

  • To validate lean body mass (LBM)-based allometric coefficients for scaling cardiac parameters.
  • To determine a novel index of left ventricular concentricity (LVC) that is independent of both LVEDV and LBM.

Main Methods:

  • Utilized UK Biobank participants (n=1638) with cardiac magnetic resonance (CMR) and dual-energy X-ray absorptiometry (DXA) data.
  • Determined allometric coefficients for scaling LVM and LVEDV using linear regression on logarithmically transformed parameters.
  • Defined a multiplicative allometric relationship for LVC, adjusting for LVEDV and LBM.

Main Results:

  • Validated LBM allometric coefficients (0.85 ± 0.06 for LVM, 0.85 ± 0.03 for LVEDV) in subjects with lower body fat.
  • Found MVR was independent of LBM but negatively associated with LVEDV in both sexes.
  • Developed LVC (LVM/(LVEDV^0.40 × LBM^0.50)), which was independent of LVEDV and LBM, increasing overlap between LV hypertrophy and concentricity.

Conclusions:

  • Successfully validated LBM-based allometric coefficients for scaling CMR-indexed parameters.
  • The novel LVC index offers an improved, volume- and LBM-independent measure for assessing ventricular remodeling.