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First Report of an Association Between Crohn's Disease and Isolated Splenic Tuberculosis in Pediatric Population

Shirin Sayyahfar1, Mona Motamedi2, Mahtab Rahbar3

  • 1Research Center of Pediatric Infectious Diseases, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran.

Middle East Journal of Digestive Diseases
|January 9, 2023
PubMed

Insights

Isolated splenic tuberculosis (TB) is rare in children, often linked to immunodeficiency. This case highlights a unique association between splenic TB and Crohn

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Gastroenterology

Background:

  • Isolated splenic tuberculosis (TB) is an exceptionally rare condition in pediatric populations.
  • Immunodeficiency, whether congenital or acquired, is typically identified as a predisposing factor for splenic TB.

Observation:

  • A 5.5-year-old child presented with isolated splenic tuberculosis.
  • The child also had a diagnosis of Crohn's disease.

Findings:

  • This case represents the first documented instance of isolated splenic TB associated with Crohn's disease in a child.
  • The co-occurrence suggests a potential link between these conditions in pediatric patients.

Implications:

  • Clinicians should consider extrapulmonary TB, particularly isolated splenic TB, in children presenting with unusual symptoms, especially in TB-endemic areas.
  • Evaluating for underlying conditions, such as Crohn's disease, is crucial in atypical TB presentations to ensure comprehensive patient management.

Keywords:
Crohn’s diseaseMycobacteriumPediatricsSplenic tuberculosisTuberculosis

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