Related Experiment Video
Updated: Aug 11, 2026

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
Published on: October 16, 2013
[Improving venous tolerance of methohexital]
To reduce venous pain from methohexital injections, pre-injection opioids and adding lidocaine to the methohexital solution are effective. These methods significantly decrease the incidence of pain, addressing prior literature contradictions.
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Venous pain following methohexital injection is a common issue.
- Previous studies showed normal saline was better than distilled water for pain reduction.
- Contradictory findings exist regarding solvent efficacy in mitigating this pain.
Purpose of the Study:
- To re-evaluate methods for reducing venous pain after methohexital injection.
- To investigate the efficacy of pre-injection opioids and lidocaine additives.
Main Methods:
- Comparative study design.
- Administration of methohexital with different pre-treatments and additives.
- Assessment of venous pain incidence.
Main Results:
- Pre-injection of an opioid significantly reduced pain.
- Adding lidocaine to the methohexital solution also strongly reduced pain incidence.
- Combined approach likely offers maximal pain reduction.
Conclusions:
- Opioid pre-administration and lidocaine addition are effective strategies to reduce methohexital-induced venous pain.
- These findings provide clear guidance for clinical practice.
- Further research may explore optimal dosages and combinations.
More Related Videos
16:19Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure
Published on: September 13, 2014
09:02Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
Published on: July 31, 2016
Related Concept Videos
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia
One of the advantages of...
Parenteral Anesthetics: Overview
Drug Accumulation During Multiple Dosing: Repetitive IV Injections
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions
Venous Thrombosis III: Interprofessional Care
Venous Thrombosis IV: Nursing Management