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Published on: April 23, 2021
Cardio-cerebrovascular complications in COVID-19 patients: A retrospective cohort study
Kwan Hong1,2, Trishna Kisiju1,2, Jeehyun Kim1,2,3
1Department of Public Health, Korea University Graduate School, Seoul, Republic of Korea.
Insights
Coronavirus disease 2019 (COVID-19) significantly increases the risk of ischemic heart disease and cerebral hemorrhage. This study confirms COVID-19 as a risk factor for cardiovascular and cerebrovascular complications.
Area of Science:
- Cardiology
- Neurology
- Infectious Diseases
Background:
- Recent studies indicate COVID-19's impact on cardiovascular and cerebrovascular systems.
- Understanding these manifestations is crucial for patient management.
Purpose of the Study:
- To investigate the association between COVID-19 infection and cardiovascular/cerebrovascular complications in South Korea.
- To quantify the risk of developing these conditions post-COVID-19.
Main Methods:
- Utilized a national COVID-19 cohort database (Jan-June 2020).
- Included COVID-19 positive cases and negative controls, excluding prior cardiovascular/cerebrovascular disease history.
- Employed Poisson and Cox regression models to estimate incidence rate ratios (IRR) and hazard ratios (HR), adjusting for demographic and clinical covariates.
Main Results:
- COVID-19 positive individuals showed a significantly higher incidence of ischemic heart disease (IRR: 1.78, HR: 3.02) and cerebral hemorrhage (IRR: 2.06, HR: 4.08) compared to controls.
- Adjusted analyses confirmed these associations, highlighting specific risks.
Conclusions:
- COVID-19 infection is a significant risk factor for acute cardiovascular complications like ischemic heart disease.
- The study demonstrates COVID-19 as a risk factor for acute cerebrovascular complications, including cerebral infarction.
Background:
Recent studies have highlighted the cardio-cerebrovascular manifestations of coronavirus disease 2019 (COVID-19).
Objective:
This study aimed to analyze the likelihood of cardiovascular and cerebrovascular manifestations among patients with COVID-19-positive individuals in South Korea.
Methods:
A cohort database for COVID-19 from the National Health Insurance Service was used which included patients diagnosed with COVID-19 between January 1 and June 4, 2020. Individuals who tested COVID-19 positive, notwithstanding the severity of the disease, were designated as cases. COVID-19- negative individuals were used as controls for the study. The exclusion criteria included people who had a history of cardiovascular and cerebrovascular diseases between 2015 and 2019. A new diagnosis of cardiovascular and cerebrovascular complications was considered the primary endpoint. The adjusted incidence rate ratio (IRR) of development of complications was estimated using log-link Poisson regression. The model was adjusted at two levels, the first one included age and sex while the second included age, sex, residence area, and level of income. The hazard ratio (HR) was estimated using Cox-proportional hazard regression analysis while adjusting for all demographic variables and covariates.
Results:
Significant results were obtained for acute conditions, such as ischemic heart disease and cerebral hemorrhage. The IRR of COVID-19- positive individuals compared with that of controls for the diagnosis of ischemic heart disease was 1.78 (1.57-2.02; 95% confidence interval [CI]) when adjusted for age and sex. HR was calculated as 3.02 (2.19-4.17; 95% CI) after adjusting for the covariates. In case of cerebral hemorrhage, the adjusted IRR was 2.06 (1.25-3.40; 95% CI) and the adjusted HR was 4.08 (0.90-19.19; 95% CI).
Conclusion:
The findings of our study suggest that COVID-19 infection can be a significant risk factor for acute cardiovascular complications, such as ischemic heart disease and acute cerebrovascular complications, such as cerebral infarction, after properly adjusting for covariates.
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