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Updated: Aug 14, 2025

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
Published on: May 21, 2018
The role of NLRP3 inflammasome in digestive system malignancy
Cen-Cen Sun1, Li Li2,3, Hou-Quan Tao2,3
1Basic Medical Experimental Teaching Center, Zhejiang University, Hangzhou, China.
Abstract:
Digestive system malignancies, the most common types of cancer and a major cause of death in the worldwide, are generally characterized by high morbidity, insidious symptoms and poor prognosis. NLRP3 inflammasome, the most studied inflammasome member, is considered to be crucial in tumorigenesis. In this paper, we reviewed its pro-tumorigenic and anti-tumorigenic properties in different types of digestive system malignancy depending on the types of cells, tissues and organs involved, which would provide promising avenue for exploring new anti-cancer therapies.
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