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Updated: Aug 14, 2025

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
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Frizzled receptors in melanomagenesis: From molecular interactions to target identification

Sheikh A Umar1, Bo Dong1, Minakshi Nihal2

  • 1Department of Dermatology, University of Wisconsin-Madison, Madison, WI, United States.

Frontiers in Oncology
|January 9, 2023
PubMed

Insights

Frizzled (FZD) receptors are key in development and cancer. In melanoma, specific FZDs drive tumor growth and spread through WNT pathways, offering new therapeutic targets.

Area of Science:

  • Molecular Biology
  • Oncology
  • Developmental Biology

Background:

  • Frizzled (FZD) proteins act as WNT ligand receptors.
  • FZDs are crucial for embryonic development and tissue maintenance.
  • Dysregulated FZD signaling is implicated in various cancers, including melanoma.

Purpose of the Study:

  • To review the role of individual FZDs in melanoma.
  • To discuss the involvement of canonical and non-canonical WNT pathways in melanoma.
  • To highlight therapeutic strategies targeting FZD receptors for melanoma treatment.

Main Methods:

  • Literature review of recent studies on FZDs in melanoma.
  • Analysis of FZD involvement in WNT/β-catenin and PCP signaling.
  • Examination of current therapeutic approaches targeting FZD receptors.

Main Results:

  • Three mammalian FZDs are implicated in promoting melanoma cell proliferation and invasion.
  • Activation of both canonical WNT/β-catenin and non-canonical PCP pathways by FZDs contributes to melanoma progression.
  • Targeting FZD receptors presents a promising avenue for melanoma therapy.

Conclusions:

  • Individual FZDs play significant roles in melanoma pathogenesis.
  • Both canonical and non-canonical WNT signaling pathways mediated by FZDs are critical in melanoma.
  • Developing FZD-targeting therapies holds potential for improving melanoma treatment outcomes.
Keywords:
Wnt/β-catenin signalingcancerfrizzledmelanomaplanar cell polarity

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