Development of magnetic dispersive micro-solid phase extraction of four phenolic compounds from food samples based on...

A magnetic dispersive micro-solid phase extraction technique (CS@Fe₃O₄-MD-μSPE-DESP) based on magnetic chitosan nanoparticles and a deep eutectic supramolecular solvent was developed and applied to determinations of four phenolic compounds in food samples. To prevent environmental pollution and the introduction of toxic substances, deep eutectic supramolecular solvents (DESPs), which exhibited greater desorption capacities than conventional organic solvents and deep eutectic solvents, were used as novel green eluents for the first time. Some important parameters were screened by the Plackett-Burman method and then further optimized with response surface methodology (RSM). Under the optimal conditions, the proposed method showed excellent methodological indices with linearity over the range 0.1-200.0 µg·mL^-1, R² > 0.9988, extraction recoveries above 94.8 %, and precision (RSD%) below 2.9 %. The established method finishes the process of adsorption and desorption in approximately 3 min and enhances the efficiency for determination of phenolic compounds.