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Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells
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RPN2 in cancer: An overview

Zhengxuan Han1, You Wang2, Lei Han1

  • 1Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China; Hubei Key Laboratory of Tumour Biological Behaviours, Wuhan, China; Hubei Cancer Clinical Study Center, Wuhan, China; The Clinical Medical Research Center of Peritoneal Cancer of Wuhan, Wuhan, China.

Gene
|January 9, 2023
PubMed

Insights

RPN2 is an oncogene crucial for cancer development, promoting tumor growth, metastasis, and drug resistance. Understanding its role enhances cancer prognosis and therapeutic strategies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Oncogenes and tumor suppressor genes regulate cancer phenotypes.
  • RPN2, an oncogene, encodes a protein involved in N-oligosaccharyl transferase, and its aberrant expression is noted in human malignancies.

Purpose of the Study:

  • To review the functions and clinical significance of RPN2 in cancer.
  • To enhance understanding of RPN2's role in tumorigenicity, metastasis, progression, and multi-drug resistance.

Main Methods:

  • Literature review of studies on RPN2 in human cancers.
  • Analysis of RPN2's involvement in N-glycosylation and signaling pathways.

Main Results:

  • RPN2 contributes to tumor progression, metastasis, and multi-drug resistance.
  • RPN2 is implicated in N-glycosylation and regulates multiple signaling pathways.
  • RPN2 demonstrates prognostic value and serves as a therapeutic target.

Conclusions:

  • RPN2 is a significant oncogene with diverse roles in cancer progression.
  • RPN2 holds promise as a biomarker for cancer prognosis and therapy efficacy.
Keywords:
BiomarkerCancerDrug resistanceMechanismRPN2

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