Copper-responsive liposomes for triggered cargo release employing a picolinamide-lipid conjugate
Ruhani Sagar1, Emily A Jaremba1, Jinchao Lou1
1Department of Chemistry, University of Tennessee, 1420 Circle Drive, Knoxville, TN 37996, USA. mdbest@utk.edu.
Abstract:
In this work, we report triggered content release from liposomes brought about by copper chelation to a synthetic lipid switch containing a picolinamide headgroup. Fluorescence-based dye-leakage assays showcase release of carboxyfluorescein dye cargo upon copper treatment and control of liposomal release based on copper abundance. Our results additionally show that this platform is selective for copper and is accompanied by significant changes to liposome properties upon treatment with this ion.
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