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Updated: Aug 14, 2025

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
[Salivary gland tumors-an overview : Advances in molecular characterization: Part II]
Niels J Rupp1,2, Sandra N Freiberger3
1Institut für Pathologie und Molekularpathologie, Universitätsspital Zürich, Zürich, Schweiz, Schmelzbergstr. 12, 8091. niels.rupp@usz.ch.
Abstract:
The second part of the article is devoted to the molecular characteristics of epithelial-myoepithelial carcinoma, polymorphous adenocarcinoma, myoepithelial carcinoma, basal cell adenocarcinoma, and salivary duct carcinoma. In addition, the new entities mucinous adenocarcinoma, sclerosing microcystic adenocarcinoma, and microsecretory adenocarcinoma are summarized. The molecular genotype can also be very helpful in diagnosing most of these entities. In this regard, overexpression of the androgen receptor and/or human epidermal growth factor receptor 2 (HER2)/neu can support diagnosis in the appropriate histopathologic context and may serve as a potential target for therapy in salivary duct carcinoma.
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