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[Systemic Candida infections].

M T Esque Ruiz1, E Alvarez, H Lavilla

  • 1Departamento de Neonatología, Casa Provincial de Maternidad, Barcelona.

Anales Espanoles De Pediatria
|August 1, 1987
PubMed
Summary
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Neonatal systemic candidiasis occurred in 8.3% of admitted newborns. Antifungal treatment showed effectiveness but also potential renal toxicity in infants.

Area of Science:

  • Neonatal Medicine
  • Infectious Diseases
  • Mycology

Context:

  • Systemic candidiasis is a serious fungal infection in newborns.
  • Incidence rates in neonatal intensive care units (NICUs) require careful monitoring.
  • Early diagnosis and treatment are crucial for patient outcomes.

Purpose:

  • To summarize clinical presentations and outcomes of neonatal systemic candidiasis.
  • To report incidence rates within a specific neonatal population.
  • To evaluate the efficacy and adverse effects of antifungal treatments.

Summary:

  • Seven cases of neonatal systemic candidiasis were identified, with an incidence of 8.3% among all admitted newborns and 3.7% in the NICU.
  • Clinical presentations were non-specific; five blood cultures were positive, and two neonates developed meningitis.

Related Experiment Videos

  • Two cases resulted in mortality. Treatment with amphotericin B and 5-fluorocytosine was administered to six infants, with one experiencing renal toxicity.

    • Impact:

    • Highlights the significant burden of systemic candidiasis in neonatal populations.
    • Underscores the need for heightened clinical suspicion due to non-specific symptoms.
    • Informs treatment strategies and emphasizes monitoring for adverse effects like renal toxicity.