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[Systemic Candida infections]
M T Esque Ruiz1, E Alvarez, H Lavilla
1Departamento de Neonatología, Casa Provincial de Maternidad, Barcelona.
Anales Espanoles De Pediatria
|August 1, 1987
Abstract:
Seven cases of neonatal systemic candidiasis are summarized. This means an incidence of 8.3% respect total amount of newborns admitted and 3.7% of babies admitted in the intensive care unit. Clinical presentation was not specific. Five blood cultures were positive and in two cases meningitis was recognized. Two cases died. Six cases were treated with amphotericin B and 5-fluorocytosine and in one case renal toxicity appear.
Insights
Neonatal systemic candidiasis occurred in 8.3% of admitted newborns. Antifungal treatment showed effectiveness but also potential renal toxicity in infants.
Area of Science:
- Neonatal Medicine
- Infectious Diseases
- Mycology
Context:
- Systemic candidiasis is a serious fungal infection in newborns.
- Incidence rates in neonatal intensive care units (NICUs) require careful monitoring.
- Early diagnosis and treatment are crucial for patient outcomes.
Purpose:
- To summarize clinical presentations and outcomes of neonatal systemic candidiasis.
- To report incidence rates within a specific neonatal population.
- To evaluate the efficacy and adverse effects of antifungal treatments.
Summary:
- Seven cases of neonatal systemic candidiasis were identified, with an incidence of 8.3% among all admitted newborns and 3.7% in the NICU.
- Clinical presentations were non-specific; five blood cultures were positive, and two neonates developed meningitis.
- Two cases resulted in mortality. Treatment with amphotericin B and 5-fluorocytosine was administered to six infants, with one experiencing renal toxicity.
Impact:
- Highlights the significant burden of systemic candidiasis in neonatal populations.
- Underscores the need for heightened clinical suspicion due to non-specific symptoms.
- Informs treatment strategies and emphasizes monitoring for adverse effects like renal toxicity.