Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Types of Toxins01:36

Types of Toxins

1.8K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.8K
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

297
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
297
Toxic Reactions: Overview01:26

Toxic Reactions: Overview

1.1K
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
1.1K
Factors Affecting Respiration01:24

Factors Affecting Respiration

5.6K
Respiration is a crucial physiological function involving exchanging oxygen (O2) and carbon dioxide (CO2) between an organism and its environment. Various factors can impact this essential process:
5.6K
Requirements for Human Life01:26

Requirements for Human Life

8.5K
The Earth and its atmosphere have provided humans with air, water, and food, but these are not the only requirements for survival. Humans also require a specific range of temperature and pressure that the Earth and its atmosphere provides.
Oxygen
Atmospheric air is only about 20 percent oxygen, but that oxygen is a key component of the chemical reactions that keep the body alive, including the reactions that produce ATP. Brain cells are susceptible to a lack of oxygen because they require a...
8.5K
Acute Respiratory Failure-III01:30

Acute Respiratory Failure-III

260
Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without...
260

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mastering Snow Analysis: Enhancing Sampling Techniques and Introducing ACF Extraction Method with Applications in Svalbard.

Molecules (Basel, Switzerland)·2024
Same author

Particle and gas phase sampling of PCDD/Fs and dl-PCBs by activated carbon fiber and GC/MS analysis.

Environmental science and pollution research international·2023
Same author

Molecular signatures of organic particulates as tracers of emission sources.

Environmental science and pollution research international·2022
Same author

Indexes of tobacco smoke contribution to environmental particulates based on molecular fingerprints of alkanes.

Environmental science and pollution research international·2022
Same author

[Methodology to evaluate occupational exposure to chemical contaminants at high altitude].

Archivos de prevencion de riesgos laborales·2021
Same author

CNN-Based Classifier as an Offline Trigger for the CREDO Experiment.

Sensors (Basel, Switzerland)·2021

Related Experiment Video

Updated: Aug 14, 2025

In vitro Cell Culture Model for Toxic Inhaled Chemical Testing
05:44

In vitro Cell Culture Model for Toxic Inhaled Chemical Testing

Published on: May 8, 2014

10.8K

High altitude underground mining. Acclimatization and possible toxicological risks.

Margarita Zamora-Saa1, Jilberto Zamora-Saa2,3, Alessandro Bacaloni4

  • 1Fundación Instituto Profesional Duoc UC, Santiago, Chile.

Giornale Italiano Di Medicina Del Lavoro Ed Ergonomia
|January 9, 2023
PubMed
Summary
This summary is machine-generated.

High-altitude miners exhibit acclimatization but face risks from hypobaric hypoxia and workplace toxins. Increased minute ventilation suggests potential health concerns requiring further investigation into combined exposure effects.

Keywords:
AcclimatizationHypobaric hypoxiaMiners in High altitudeUnusual work shifts

More Related Videos

Using Flexible Gold-Titanium Reaction Cells to Simulate Pressure-Dependent Microbial Activity in the Context of Subsurface Biomining
13:11

Using Flexible Gold-Titanium Reaction Cells to Simulate Pressure-Dependent Microbial Activity in the Context of Subsurface Biomining

Published on: October 5, 2019

6.7K
Assessment of the Acute Inhalation Toxicity of Airborne Particles by Exposing Cultivated Human Lung Cells at the Air-Liquid Interface
10:10

Assessment of the Acute Inhalation Toxicity of Airborne Particles by Exposing Cultivated Human Lung Cells at the Air-Liquid Interface

Published on: February 23, 2020

7.1K

Related Experiment Videos

Last Updated: Aug 14, 2025

In vitro Cell Culture Model for Toxic Inhaled Chemical Testing
05:44

In vitro Cell Culture Model for Toxic Inhaled Chemical Testing

Published on: May 8, 2014

10.8K
Using Flexible Gold-Titanium Reaction Cells to Simulate Pressure-Dependent Microbial Activity in the Context of Subsurface Biomining
13:11

Using Flexible Gold-Titanium Reaction Cells to Simulate Pressure-Dependent Microbial Activity in the Context of Subsurface Biomining

Published on: October 5, 2019

6.7K
Assessment of the Acute Inhalation Toxicity of Airborne Particles by Exposing Cultivated Human Lung Cells at the Air-Liquid Interface
10:10

Assessment of the Acute Inhalation Toxicity of Airborne Particles by Exposing Cultivated Human Lung Cells at the Air-Liquid Interface

Published on: February 23, 2020

7.1K

Area of Science:

  • Occupational Health
  • Environmental Physiology
  • Altitude Medicine

Background:

  • Mine workers at high altitudes face unique physiological challenges.
  • Understanding responses to hypobaric hypoxia is crucial for worker health.
  • Key parameters include ventilation, heart rate, and hemoglobin saturation.

Purpose of the Study:

  • To measure initial physiological responses to hypobaric hypoxia in high-altitude miners.
  • To assess changes in ventilation minute, heart rate, and hemoglobin saturation.
  • To contrast these responses with those of workers at lower altitudes.

Main Methods:

  • Studied Chilean miners in an underground mine at 3,070–3,656 masl.
  • Implemented a 4-day work, 4-day rest shift system.
  • Compared high-altitude data with results from workers at 800 masl.

Main Results:

  • Miners with <6 months exposure or exposed to contaminants showed hemoglobin saturation <90%.
  • Heart rate increased with acute/chronic high-altitude hypoxia exposure.
  • Miners' resting heart rate was lower than non-exposed clerks; minute ventilation was higher at altitude.

Conclusions:

  • Most miners demonstrated acclimatization responses to high altitude.
  • Elevated minute ventilation indicates a risk from inhaled workplace toxins.
  • Urgent research is needed on combined effects of high-altitude hypobaric hypoxia and mine toxins.