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Radiotheranostics in oncology: Making precision medicine possible
Eric O Aboagye1, Tara D Barwick1,2, Uwe Haberkorn3,4,5
1Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital, London, UK.
CA: a Cancer Journal for Clinicians
|January 9, 2023
Summary
Theranostics precisely targets disease using diagnostic and therapeutic tools. This precision medicine approach shows high response rates in cancers like prostate cancer and neuroendocrine tumors.
Area of Science:
- Theranostics
- Precision Medicine
- Oncology
Background:
- Theranostics integrates diagnostics and therapeutics for targeted disease treatment.
- Oncology is a leading field for theranostics innovation.
- Advances in molecular targeting, imaging, and drug delivery enable theranostics.
Purpose of the Study:
- To highlight the evolving field of theranostics in precision medicine.
- To discuss the role of radiopharmaceuticals in theranostics.
- To emphasize the potential of theranostics in oncology.
Main Methods:
- Utilizing diagnostic tools to identify disease-specific targets.
- Employing similar or identical tools for targeted therapy.
- Developing and applying radiopharmaceuticals for imaging and treatment.
Main Results:
- Radiotheranostics is becoming standard for prostate cancer (PSMA) and neuroendocrine tumors (SSTR2).
- Significant complete and partial responses observed in patients with high metastatic burden.
- High likelihood of response in patients who meet theranostic targeting criteria.
Conclusions:
- Theranostics offers a high therapeutic index, maximizing efficacy while minimizing toxicity.
- The success in specific cancers fuels the search for broader radiotheranostic applications.
- Patient selection based on target detection is crucial for successful theranostic outcomes.
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