Pharos 2023: an integrated resource for the understudied human proteome.

Area of Science:

• Genomics
• Pharmacology
• Bioinformatics

Background:

• The Illuminating the Druggable Genome (IDG) project focuses on understudied proteins for disease biology and therapeutic development.
• Key IDG resources include the Target Central Resource Database (TCRD) for data curation and Pharos for data visualization.
• Previous releases established foundational data aggregation and access.

Purpose of the Study:

• To detail recent advancements in TCRD and Pharos, focusing on new analysis and visualization tools.
• To demonstrate how these tools facilitate exploration of disease biology and drug discovery.
• To showcase the utility of enrichment calculations and interactive charts for biological insights.

Main Methods:

• Continued development of TCRD for comprehensive target information aggregation.
• Enhancement of Pharos as a web interface for intuitive data extraction and visualization.
• Implementation of enrichment calculations and interactive heat maps/UpSet charts for data analysis.

Main Results:

• TCRD and Pharos now offer advanced tools for analyzing target, disease, and ligand data.
• Users can perform enrichment calculations on specific data subsets.
• Interactive visualizations like heat maps and UpSet charts are available for complex annotation analysis.

Conclusions:

• The updated TCRD/Pharos platform provides powerful capabilities for investigating disease biology.
• These tools empower researchers to address complex drug discovery questions through data-driven insights.
• Enhanced data analysis and visualization accelerate the understanding of druggable targets.