Related Experiment Videos
Are generic formulations equivalent to trade name topical glucocorticoids?
1Division of Dermatology, University of California-San Diego School of Medicine 92093.
Archives of Dermatology
|October 1, 1987
Summary
Generic and brand-name topical corticosteroids like triamcinolone acetonide show significant differences in effectiveness. Physicians should be aware of potential therapeutic variations when substituting generic glucocorticoid formulations.
Area of Science:
- Dermatology
- Pharmacology
- Pharmaceutical Sciences
Background:
- Increasing substitution of generic formulations for trade name topical corticosteroids.
- Need to evaluate the therapeutic equivalence of generic versus brand-name glucocorticoids.
Purpose of the Study:
- To compare the therapeutic effectiveness of trade name glucocorticoid formulations with their generic equivalents.
- To assess potential differences in vasoconstrictor activity between generic and brand-name topical steroids.
Main Methods:
- Comparison of trade name formulations (triamcinolone acetonide, fluocinolone acetonide, betamethasone valerate) with their generic equivalents.
- Utilized the vasoconstrictor assay to measure and compare the potency of different formulations.
Main Results:
- Significant differences in vasoconstrictor activity were observed between generic and trade name formulations containing the same steroid at the same concentration.
- Variations were noted in both cream and ointment vehicles, indicating formulation-dependent differences.
Conclusions:
- Generic substitutions for trade name topical corticosteroids may lead to significant differences in therapeutic effectiveness.
- Healthcare providers must be aware of these potential variations to ensure optimal patient outcomes.